Infant gut microbiota and the development of wheeze in early childhood

نویسندگان

  • Scarlet M Salas
  • Meghan B Azad
  • Tedd Konya
  • David S Guttman
  • Allan B Becker
  • Malcolm R Sears
  • James A Scott
  • Anita L Kozyrskyj
چکیده

Background Commensal gut microbes play an important role in human development and lifelong health. There is increasing evidence that disruption of the infant gut microbiota may be linked to the development of childhood allergy and asthma-related outcomes, including wheezing. Our objective was to investigate the association of infant gut microbiota diversity and composition with development of wheeze in early childhood.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Correlation of gut microbiota composition with colon adenomatous polyps

Microbiota is a collection of microorganisms that live in the oral cavity, respiratory tract and intestine of multicellular organisms. Microbiota exerts numerous physiological and pathological effects on the organism in which it resides. Increasing attention has been directed to the host-microbiota interaction, which is highly relevant to the development of carcinogenesis. Changes in the compos...

متن کامل

Gut Microbiome and Infant Health: Brain-Gut-Microbiota Axis and Host Genetic Factors

The development of the neonatal gut microbiome is influenced by multiple factors, such as delivery mode, feeding, medication use, hospital environment, early life stress, and genetics. The dysbiosis of gut microbiota persists during infancy, especially in high-risk preterm infants who experience lengthy stays in the Neonatal intensive care unit (NICU). Infant microbiome evolutionary trajectory ...

متن کامل

Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study.

BACKGROUND AND AIMS Perturbations in intestinal microbiota composition due to lifestyle changes may be involved in the development of atopic diseases. We examined gut microbiota composition in early infancy and the subsequent development of atopic manifestations and sensitisation. METHODS The faeces of 957 infants aged 1 month and participating in the KOALA Birth Cohort Study were analysed us...

متن کامل

Impact of the Gut Microbiota on Vaccine Responses

Non-responsiveness or poor responsiveness to vaccines are challenging issues in vaccine development, and efforts have been made to find out the potential reasons for these conditions. Intestinal microbiome plays a key role in regulating and development of immune system and the composition and diversity of microbiota in different individuals on the one hand, and the imbalance of intestinal micro...

متن کامل

Changes in the composition and function of the gut microbiota in celiac disease

Evidence is supported the hypothesis that any changes in the composition and function of the gut microbiota play a fundamental role in a number of chronic inflammatory diseases including celiac disease (CD). In the last decade, several culture-independent methods have been developed to identify the components of the human microbiome. The study of microbiota based on nucleic acid analysis found ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 10  شماره 

صفحات  -

تاریخ انتشار 2014